The South Sudan HIV/AIDS Program (SSHAP) works to prevent HIV among commercial sex workers, their clients and long-distance truck drivers in Central Equatoria State, Western Equatoria State and Eastern Equatoria State.Implemented by a consortium led by FHI 360 and funded by the U.S. Agency for International Development, the program uses data-driven, evidence-based and cost-effective social marketing strategies to promote protective behaviours and HIV-related services among people who are at a high risk of contracting HIV. The program also works to increase the accessibility and availability of branded and generic condoms in targeted locations. Originally called the Sudan HIV and AIDS Program, the program’s name was changed to reflect South Sudan’s new status as an independent country.