Alcohol-related liver disease (ARLD) refers to liver damage caused by excess alcohol intake. There are several stages of severity and a range of associated symptoms.
ARLD does not usually cause any symptoms until the liver has been severely damaged.
If you do experience early symptoms of ARLD, these are often quite vague, such as:
As the liver becomes more severely damaged, more obvious and serious symptoms can develop, such as :
- yellowing of the skin and whites of the eyes (jaundice)
- swelling in the legs, ankles and feet caused by a build-up of fluid (oedema)
- swelling in your abdomen caused by a build-up of fluid known as ascites
- a high temperature (fever) and shivering attacks
- very itchy skin
- hair loss
- unusually curved fingertips and nails (clubbed fingers)
- blotchy red palms
- significant weight loss
- weakness and muscle wasting
- confusion and memory problems, trouble sleeping (insomnia) and changes in your personality caused by a build-up of toxins in the brain
- passing black, tarry poo and vomiting blood as a result of internal bleeding
- a tendency to bleed and bruise more easily, such as frequent nosebleeds and bleeding gums
increased sensitivity to alcohol and drugs because the liver cannot process them
Alcohol and the liver
With the exception of the brain, the liver is the most complex organ in the body.
Its functions include:
- filtering toxins from the blood
- aiding digestion of food
- regulating blood sugar and cholesterol levels
- helping fight infection and disease
The liver is very resilient and capable of regenerating itself. Each time your liver filters alcohol, some of the liver cells die.
The liver can develop new cells, but prolonged alcohol misuse (drinking too much) over many years can reduce its ability to regenerate. This can result in serious and permanent damage to your liver.
ARLD is very common in the UK. The number of people with the condition has been increasing over the last few decades as a result of increasing levels of alcohol misuse.
Read more about the causes of ARLD.
Stages of ARLD
There are 3 main stages of ARLD, although there's often an overlap between each stage. These stages are explained below.
Alcoholic fatty liver disease
Drinking a large amount of alcohol, even for just a few days, can lead to a build-up of fats in the liver.
This is called alcoholic fatty liver disease, and is the first stage of ARLD.
Fatty liver disease rarely causes any symptoms, but it's an important warning sign that you're drinking at a harmful level.
Fatty liver disease is reversible. If you stop drinking alcohol for 2 weeks, your liver should return to normal.
Alcoholic hepatitis, which is unrelated to infectious hepatitis, is a potentially serious condition that can be caused by alcohol misuse over a longer period.
When this develops, it may be the first time a person is aware they're damaging their liver through alcohol.
Less commonly, alcoholic hepatitis can occur if you drink a large amount of alcohol in a short period of time (binge drinking).
The liver damage associated with mild alcoholic hepatitis is usually reversible if you stop drinking permanently.
Severe alcoholic hepatitis, however, is a serious and life-threatening illness.
Many people die from the condition each year in the UK, and some people only find out they have liver damage when their condition reaches this stage.
Cirrhosis is a stage of ARLD where the liver has become significantly scarred. Even at this stage, there may not be any obvious symptoms.
It's generally not reversible, but stopping drinking alcohol immediately can prevent further damage and significantly increase your life expectancy.
A person who has alcohol-related cirrhosis and does not stop drinking has a less than 50% chance of living for at least 5 more years.
Alcohol-related liver disease (ARLD) is often first suspected when tests for other medical conditions show a damaged liver. This is because the condition causes few obvious symptoms in the early stages. If a doctor suspects ARLD, they'll usually arrange a blood test to check how well your liver is working. They may also ask about your alcohol consumption.
It's important to be totally honest about how much and how often you drink alcohol to avoid further unnecessary testing. This could lead to a delay in the treatment you need.
Blood tests used to assess the liver are known as liver function tests. But liver function tests can be normal at many stages of liver disease. Blood tests can also detect if you have low levels of certain substances, such as a protein called serum albumin, which is made by the liver. A low level of serum albumin suggests your liver is not functioning properly. A blood test may also look for signs of abnormal blood clotting, which can indicate significant liver damage.
These are described below.
Scans may be needed to produce detailed images of your liver. This may include:
Some scans may also measure the stiffness of the liver, which is a good indication of whether your liver is scarred.
During a liver biopsy, a fine needle is inserted into your body (usually between your ribs). A small sample of liver cells is taken and sent to a laboratory to be examined under a microscope. The biopsy is usually carried out under local anaesthetic, either as a day case or with an overnight stay in hospital. Your liver tissue will be examined to determine the degree of scarring in the liver and the cause of the damage.
An endoscope is a long, thin, flexible tube with a light and a video camera at one end. During an endoscopy, the instrument is passed down your oesophagus (the long tube that carries food from the throat to the stomach) and into your stomach. Pictures of your oesophagus and stomach are transmitted to an external screen. The doctor will be looking for swollen veins (varices), which are a sign of cirrhosis.
Successful treatment for alcohol-related liver disease (ARLD) often depends on whether someone is willing to stop drinking alcohol and make changes to their lifestyle.
Stopping drinking alcohol
Treatment for ARLD involves stopping drinking alcohol. This is known as abstinence, which can be vital, depending on what stage the condition is at. If you have fatty liver disease, the damage may be reversed if you abstain from alcohol for at least 2 weeks. After this point, it's usually safe to start drinking again if you stick to the NHS guidelines on alcohol consumption.
If you have a more serious form of ARLD (alcoholic hepatitis or cirrhosis) lifelong abstinence is recommended. This is because stopping drinking is the only way to prevent your liver damage getting worse and potentially stop you dying of liver disease. Stopping drinking is not easy, especially as an estimated 70% of people with ARLD have an alcohol dependency problem.
Nevertheless, if you have alcohol-related cirrhosis or alcoholic hepatitis and do not stop drinking, no medical or surgical treatment can prevent liver failure.
If you're abstaining from alcohol, you may suffer withdrawal symptoms. These will be at their worst for the first 48 hours, but should start to improve as your body adjusts to being without alcohol. This usually takes 3 to 7 days from the time of your last drink. Many people initially experience disturbed sleep when abstaining from alcohol, but in most cases their sleep pattern returns to normal within a month.
In some cases, you may be advised to reduce your alcohol intake in a gradual and planned way to help avoid withdrawal problems. You may also be offered a medication called a benzodiazepine and psychological therapy, such as cognitive behavioural therapy (CBT), to help you through the withdrawal process.
Some people need to stay in hospital or a specialist rehabilitation clinic during the initial withdrawal phases so their progress can be closely monitored. If you're staying at home, you'll regularly see a nurse or another health professional. You might see them at home, your GP surgery or a specialist NHS service.
Once you have stopped drinking, you may need further treatment to help ensure you do not start drinking again. The first treatment usually offered is psychological therapy. This involves seeing a therapist to talk about your thoughts and feelings, and how these affect your behaviour and wellbeing. If psychological therapy alone is not effective, you may also need medicine to help you abstain from alcohol, such as:
Many people with alcohol dependence find it useful to attend self-help groups to help them stop drinking.One of the most well-known is Alcoholics Anonymous, but there are many other groups that can help.
Diet and nutrition
Malnutrition is common in people with ARLD, so it's important to eat a balanced diet to make sure you get all the nutrients you need. Avoiding salty foods and not adding salt to foods you eat can reduce your risk of developing swelling in your legs, feet and tummy caused by a build-up of fluid.
The damage to your liver can also mean it's unable to store glycogen, a carbohydrate that provides short-term energy.
When this happens, the body uses its own muscle tissue to provide energy between meals, which leads to muscle wasting and weakness. This means you may need extra energy and protein in your diet.
Healthy snacking between meals can top up your calories and protein. It may also be helpful to eat 3 or 4 small meals a day, rather than 1 or 2 large meals.
Your GP can advise you on a suitable diet or, in some cases, refer you to a dietitian.
In the most serious cases of malnutrition, nutrients may need to be provided through a feeding tube inserted through the nose and into the stomach.
Medication for symptoms
The use of medication to directly treat ARLD is controversial. Many experts have argued there's limited evidence for its effectiveness.
For people with severe alcoholic hepatitis, treatment in hospital may be necessary.
Specific treatment with corticosteroids or pentoxifylline medication may be used to reduce inflammation of the liver in some people with this condition.
Nutritional support is also an important part of treatment in these cases.
Other medications that have been used to treat liver damage include:
- anabolic steroids (a more powerful type of steroid medication)
- ropylthiouracil (a type of medicine originally designed to treat overactive thyroid glands)
But there's a lack of good evidence that these help and they're no longer used for severe alcoholic hepatitis.
In the most serious cases of ARLD, the liver loses its ability to function, leading to liver failure.
A liver transplant is currently the only way to cure irreversible liver failure. A liver transplant may be considered if:
- you develop progressive liver failure, despite not drinking alcohol
- you're otherwise well enough to survive such an operation
- you commit to not drinking alcohol for the rest of your life
Taking medications with ARLD
If you have ARLD, it's important to talk to your GP or pharmacist before taking over-the-counter or prescription medications.
ARLD can affect the way the body processes some medications.
The most effective way to prevent ARLD is to stop drinking alcohol or stick to the recommended limits:
- men and women are advised not to regularly drink more than 14 units a week
- spread your drinking over 3 days or more if you drink as much as 14 units a week
A unit of alcohol is equal to about half a pint of normal-strength lager or a pub measure (25ml) of spirits.
Even if you have been a heavy drinker for many years, reducing or stopping your alcohol intake will have important short- and long-term benefits for your liver and overall health.
A number of serious complications can develop if you have alcohol-related liver disease (ARLD).
Portal hypertension and varices
It occurs when the blood pressure inside your liver has risen to a potentially serious level. When the liver becomes severely scarred, it's harder for blood to move through it. This leads to an increase in the pressure of blood around the intestines.
The blood must also find a new way to return to your heart. It does this by using smaller blood vessels. But these vessels are not designed to carry the weight of blood, so they can become stretched out and weakened. These weakened blood vessels are known as varices. If the blood pressure rises to a certain level, it can become too high for the varices to cope with, causing the walls of the varices to split and bleed.
This can cause long-term bleeding, which can lead to anaemia.
Alternatively, the bleeding can be rapid and massive, causing you to vomit blood and pass stools that are very dark or tar-like.
Split varices can be treated by using an endoscope to locate the varices. A tiny band can then be used to seal the base of the varices.
A person with portal hypertension may also develop a build-up of fluid in their abdomen (tummy) and around the intestines. This fluid is known as ascites. Initially, this can be treated with water tablets (diuretics). If the problem progresses, many litres of fluid can build up, which needs to be drained. This is a procedure known as paracentesis and involves a long, thin tube being placed into the fluid through the skin under local anaesthetic.
One of the problems associated with the development of ascites is the risk of infection in the fluid (spontaneous bacterial peritonitis).
This is a potentially very serious complication and is linked to an increased risk of kidney failure and death.
One of the most important functions of the liver is to remove toxins from your blood.
If the liver is unable to do this due to hepatitis or cirrhosis, the levels of toxins in the blood increase.
A high level of toxins in the blood due to liver damage is known as hepatic encephalopathy.
Symptoms of hepatic encephalopathy include:
- muscle stiffness
- muscle tremors
- difficulty speaking
- in very serious cases, a coma
Hepatic encephalopathy may require hospital admission. In hospital, body functions are supported and medicine is used to remove toxins from the blood.
Damage to the liver can weaken the immune system.
This can make the body more vulnerable to infection, particularly urinary infections and respiratory infections (such as pneumonia).
Liver damage due to heavy drinking over many years can also increase your risk of developing liver cancer.
Over the past few decades, rates of liver cancer in the UK have risen sharply due to increased levels of alcohol misuse.
It's estimated 3 to 5% of people with cirrhosis will develop liver cancer every year.